Now, I don’t do cocaine 
but I like to read about things like these. Some geniuses actually thought about using cholera proteins and putting cocaine on them.
What this does is create an immune response to cholera proteins but also to cocaine. The immune system attacks it and you can’t get high
Smaaart. But… I wouldn’t want any cholera in my bloodstream, inactivated or not
The vaccine is up for approval, read about it here.